Medication delivery pen having an improved clutch assembly

ABSTRACT

An improved medication delivery pen is provided for injecting fluids such as insulin within body tissue. The medication delivery pen includes a mechanism that prevents the removal of a cartridge unless an injector button on the medication pen is in a predefined position, a bayonet attachment and an improved clutch assembly in a dose setting mechanism that provides improved control over the torque necessary to rotate a units counter ring in the medication delivery pen using a dose setting knob.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The subject invention relates to an improved medication delivery pen.

2. Description of Related Art

Hypodermic syringes are used to deliver selected doses of medication topatients. The prior art hypodermic syringe includes a syringe barrelhaving opposed proximal and distal ends. A cylindrical chamber wallextends between the ends and defines a fluid receiving chamber. Theproximal end of the prior art syringe barrel is substantially open andreceives a plunger in sliding fluid tight engagement. The distal end ofthe prior art syringe barrel includes a passage communicating with thechamber. A needle cannula may be mounted to the distal end of the priorart syringe barrel, such that the lumen of the needle cannulacommunicates with the passage and the chamber of the syringe barrel.Movement of the plunger in a proximal direction draws fluid through thelumen of the needle cannula and into the chamber. Movement of theplunger in a proximal-to-distal direction urges fluid from the chamberand through the lumen of the needle cannula.

Medication to be injected with the prior art hypodermic syringe often isstored in a vial having a pierceable elastomeric seal. Medication in theprior art vial is accessed by piercing the elastomeric seal with theneedle cannula. A selected dose of the medication may be drawn into thechamber of the syringe barrel by moving the plunger a selected distancein a proximal direction. The needle cannula may be withdrawn from thevial, and the medication may be injected into a patient by moving theplunger in a distal direction.

Some medication, such as insulin is self-administered. The typicaldiabetes patient will require injections of insulin several times duringthe course of a week or day. The required dose of insulin will vary frompatient to patient, and for each patient may vary during the course ofthe day and from day to day. Each diabetes patient will establish aregimen that is appropriate for his or her own medical condition and forhis or her lifestyle. The regimen typically includes some combination ofa slow or medium acting insulin and a faster acting insulin. Each ofthese regimens may require the diabetes patient to periodicallyself-administer insulin in public locations, such as places ofemployment or restaurants. The required manipulation of the standardprior art hypodermic syringe and vial can be inconvenient andembarrassing in these public environments.

Medication delivery pens have been developed to facilitate theself-administration of medication. One prior art medication delivery pendescribed in U.S. Pat. No. 5,279,585 includes a vial holder into which avial of insulin or other medication may be received. The vial holder isan elongate generally tubular structure with proximal and distal ends.The distal end of the prior art vial holder includes mounting means forengaging a double-ended needle cannula. The proximal end also includesmounting means for engaging a driver and dose setting apparatus asexplained further below. A disposable vial for use with the prior artvial holder includes a distal end having a pierceable elastomeric sealthat can be pierced by one end of a double-ended needle cannula. Theproximal end of this prior art vial includes a plunger slidably disposedin fluid tight engagement with the cylindrical wall of the vial. Thisprior art medication delivery pen is used by inserting the vial ofmedication into the vial holder. A prior art pen body then is connectedto the proximal end of the vial holder. The pen body includes a dosesetting apparatus for designating a dose of medication to be deliveredby the pen and a driving apparatus for urging the plunger of the vialdistally for a distance corresponding to the selected dose.

The user of the pen mounts a prior art double-ended needle cannula tothe distal end of the vial holder such that the proximal point cannulaof the needle cannula pierces the elastomeric seal on the vial. The userthen selects a dose and operates the pen to urge the plunger distally todeliver the selected dose. The user then removes and discards the needlecannula, and keeps the prior art medication delivery pen in a convenientlocation for the next required medication administration. The medicationin the vial will become exhausted after several such administrations ofmedication. The user then separates the vial holder from the pen body.The empty vial may then be removed and discarded. A new vial can beinserted into the vial holder, and the vial holder and pen body can bereassembled and used again as explained above.

The above described reusable medication delivery pen is effective andmuch more convenient for self-administration of medication than thetypical hypodermic syringe and separate medication vial. However, it hasbeen found that there is the need for additional features andimprovements for such a medication delivery pen. For example, there isthe need to prevent removal of the vial unless the injector button ofthe medication delivery pen is in a selected position, to provideimproved control over the torques available or necessary to rotate aunit indicator using a dose setting apparatus, and to generallystrengthen or otherwise improve the dose setting apparatus in themediation delivery pen.

SUMMARY OF THE INVENTION

The present invention is directed to providing a medication delivery penhaving the features and improvements set forth above.

One object of the present invention is to provide a mechanism in themedication delivery pen that prevents the removal of a vial or cartridgeunless the injector button of the medication pen is in a selectedposition. The feature is provided by using a pair of bayonet connectionson the cartridge retainer to activate a locking mechanism in the penwhen the cartridge retainer is rotated. In particular, when the injectorbutton is in the up position, the pivot shafts on the half-nuts in thepen prevent rotation of a locking sleeve which prevents removal of thecartridge retainer and cartridge. However, when the injector button isin the down position the pivot shafts on the half nuts in the pen do notprevent rotation of the locking sleeve, which then allows the cartridgeretainer to rotate and the bayonet connections to be separated from thepen's housing to remove the cartridge.

Another object of the present invention is to improve the clutchassembly in the medication delivery pen to provide more control over thetorques necessary to rotate the unit indicator in the pen using therotation of a dosing knob in the dose setting apparatus.

A third object of the present invention is to improve the dosedispensing apparatus to provide more definite control over the dosedispensing operation by preventing skewing of the drive mechanism.

These and other aspects, features and advantages of the presentinvention will become apparent from the following detailed descriptiontaken in conjunction with the accompanying drawings.

DESCRIPTION OF THE DRAWINGS

FIG. 1 is a perspective view of a medication delivery pen of the subjectinvention;

FIG. 2 is a perspective view of the medication delivery pen shown inFIG. 1 with the plunger extended;

FIG. 3 is a perspective view of the medication delivery pen shown inFIG. 1 with the plunger moving axially during an injection;

FIG. 4 is a perspective view of the medication delivery pen shown inFIG. 1 with the cartridge retainer removed;

FIGS. 5a and 5b are exploded perspective views of the pen shown in FIG.1 further including a needle assembly;

FIG. 6 is an enlarged perspective of the clutch assembly;

FIG. 7 is an exploded perspective view of the medication delivery penshown in FIG. 1 with the cartridge retainer removed;

FIG. 8 is another perspective view of the medication delivery pen shownin FIG. 1 with the cartridge retainer attached and locked onto the upperbody;

FIG. 9 is a cross sectional view taken along lines 9--9 as shown in FIG.1;

FIG. 10 is a cross sectional view taken along lines 10--10 as shown inFIG. 2;

FIG. 11 is a cross sectional view taken along lines 11--11 as shown inFIG. 4;

FIG. 12 is an enlarged cross sectional view of the medication deliverypen shown in FIGS. 2 and 10 to more clearly show the clutch assembly;

FIG. 13 is an enlarged cross sectional view of the zero detection clipshown in FIG. 5b; and

FIG. 14 is a cross sectional view taken along lines 14--14 as shown inFIG. 13.

DETAILED DESCRIPTION

An improved injection device 10 for injecting insulin or othermedication is provided by the present invention. As shown in FIGS. 1-3,the device includes an adjusting knob 12, an upper body 14, a centerbody 16, and a cartridge retainer 18. All of these elements have agenerally cylindrical configuration and are arranged coaxially to definea generally cylindrical housing 20 which can easily be handled by apatient or medical attendant.

Referring to FIGS. 4, 5a and 7-12, a plunger 22 is at least partiallypositioned within the portion of housing 20 defined by adjusting knob12, upper body 14 and center body 16. Plunger 22 includes a hollow,substantially cylindrical body 22a including a band of radiallyprojecting splines 22b extending outwardly therefrom. A pair of opposingprojections 22c extend radially inwardly from the front end of thecylindrical body 22a. As shown in FIGS. 5a and 5b, the rear end ofplunger 22 is secured to a hub 25 having a rotatable push button 24snapped therein. Push button 24 fits partially within adjusting knob 12when plunger 22 is fully inserted within housing 20.

A lead screw 26 is positioned within and coaxially with plunger 22 andincludes an enlarged front end 26a and a tapered rear end 26b, connectedby an elongate threaded body 26c. A pair of longitudinal grooves 26d areformed within threaded body 26c and receive the radially inwardlyextending projections 22c of plunger 22. Lead screw 26 is accordinglyrotatable with plunger 22 and capable of sliding axially with respect toplunger 22.

A pair of half-nuts 28 are positioned within center body 16, with eachhalf-nut 28 including a semi-cylindrical body portion 28a and a radiallyenlarged end portion 28b. The front end of each half-nut 28 includesthreads 28c that are used to threadably engage with lead screw 26 andthe rear end of each half-nut 28 includes a pivot shaft 28d thatreceives a metal pin 28e to provide an axis about which each half-nut 28can pivot. Metal pins 28e inserted in each pivot shaft 28d also providemore definite control over the dose setting operation, described below,and prevent skewing of half nuts 28 on threaded lead screw 26. Bodyportions 28a of half-nuts 28 are positioned at least partially within alocking ring 30 having a hollow, generally cylindrical body portion 30adefining a generally elliptical passage 30e for receiving half-nuts 28.A front end 30b of locking ring 30 is radially enlarged and includes apair of angular projections 30c that extend axially from the front endof locking ring 30 and the side of locking ring 30 includes a pair ofpins 30d. The proximal end 18b of cartridge retainer 18 includes a pairof angular projections 18c that are spaced to receive angularprojections 30c when cartridge retainer 18 is mounted on housing 20,which is described further below.

A helical coil spring 32 is positioned over locking ring 30 andhalf-nuts 28 and through locking sleeve 31, with one end of coil spring32 bearing against the radially enlarged portions 28b of half-nuts 28while the opposite end of coil spring 32 bears against the radiallyenlarged front end 30b of locking ring 30. Front end 30b of locking ring30 mounts within center body 16 which also receives finishing ring 29.The rear end portion 28b of half-nuts 28 abut splines 22b of plunger 22,as shown in FIG. 9.

Locking ring 30 is slidably mounted within locking sleeve 31 such thatthe pair of pins 30d on locking ring 30 are mounted and travel withinslot 31a at a distal end of locking sleeve 31. With this structurelocking ring 30 is axially movable within locking sleeve 31 but rotateswith locking sleeve 31. Locking sleeve 31 also includes a pair ofL-shaped grooves 31b that slidably receive each of the shafts 28d onhalf-nuts 28. Each pivot shaft 28d in conjunction with its respectiveL-shaped groove 31b on locking sleeve 31 and a long groove 16c withincenter body 16 provides a mechanism that prevents the removal ofcartridge retainer 18 and cartridge 46 from housing 20, unless injectorbutton 24 is in a down or loading position. This feature is more clearlyshown in FIGS. 7 and 8. In FIG. 7 injector button 24 is in the down orloading position and device 10 is in the proper position for receivingcartridge retainer 18 and, in particular, lugs 18a can enter slot 16a ofcenter body 16. As shown in FIG. 7, locking ring 30 is oriented so thattabs 30c do not block access to slot 16a and in this orientation pivotshafts 28d of half-nuts 28 are located in notches 31e at the end of eachlower leg 31d of L-shaped groove 31b. After a cartridge 46 has beenloaded into cartridge retainer 18, cartridge retainer 18 is mated withcenter housing 16 such that lugs 18a enter slot 16a. Then, as shown inFIG. 8, cartridge retainer 18 is rotated in a clockwise direction suchthat lugs 18a drive tabs 30c in a clockwise direction which moveslocking sleeve 31 and causes pivot shaft 28d to slide out of each notch31e and into each leg 31d of each L-shaped groove 31b. At this point,spring 32 drives half-nuts 28 in the proximal direction to extendinjector button 24 from the proximal end of assembly 10, if dosesettings rings 36 and 38 are set to zero.

As shown in FIG. 5b, upper body 14 includes an opening 14a in which atransparent window 34 is mounted. A units counter ring 36 and a tenscounter ring 38 are positioned in adjoining relation beneath window 34,with both counter rings 36 and 38 including outer surfaces havingnumerals thereon visible through window 34.

An O-ring 40 made from an elastomeric material is mounted in unitscounter ring 36 to hold a transmission key 44 in position. Transmissionkey 44 is provided for engaging and disengaging the units and tenscounter rings 36, 38, and is located within a channel formed in unitscounter ring 36, as shown in FIG. 12. A zero detection clip 42, moreclearly shown in FIGS. 13 and 14, is positioned between the innersurfaces of counter rings 36 and 38 and the outer surface of plunger 22.Zero detection clip 42, as shown in FIGS. 5b, 13 and 14, includes agenerally cylindrical body 42a having a radially enlarged front end 42b.A lower spring member 42c extends axially within a slot formed withinclip body 42a and includes a ridge 42d that is engageable with groove38a formed within the inner surface of tens counter ring 38, as bestshown in FIG. 14. Zero detection clip 42 also includes an axiallyextending upper spring member 42e, the position of which is controlledby the rotational positions of the units and tens counter rings 36, 38.Upper spring member 42e includes a distal surface 42f that is engageablewith splines 22b of plunger 22 when pushed into its active position byunits counter ring 36 or by tens counter ring 38. The inner surface ofunits counter ring 36 functions as a cam and controls the radialposition of upper spring member 42e of the zero detection clip 42.

The inner surface of units counter ring 36 is splined, with the splinesurface being engageable with small splines 22d of plunger 22.Engagement between ring 36 and plunger 22 occurs when spring 32 is inthe extended position shown in FIG. 10. Units counter ring 36 is thendriven by adjusting knob 12 through a specially designed clutch detentspring 15, more clearly shown in FIG. 6. Clutch detent spring 15includes a ring 15a having four internal tabs 15b that mount ring 15aonto units counter ring 36 and four legs 15c that are driven by rotationof adjusting knob 12. The present invention provides a clutch detentspring 15 that is made of a flexible metal that can be manufactured toprovide a predetermined slip torque action between adjusting knob 12 andunits counter ring 36.

FIG. 6 is an enlarged perspective view of clutch detent spring 15 andshows its connection with adjusting knob 12, clutch nut 13 and unitscounter ring 36. Clutch detent spring 15 includes ring 15a having fourouter legs 15c extending in the distal direction with each leg 15chaving a protrusion 15d thereon extending away from rotational axis 15rof clutch detent spring 15. Internal tabs 15b correspond to notches 36aon units counter ring 36 that receive a respective internal tab 15b andhold clutch detent spring 15 onto units counter ring 36 together withthe clutch nut 13 that is threaded onto units counter ring 36. Whenunits counter ring 36 with clutch detent spring 15 mounted thereon isassembled into adjusting knob 12, protrusions 15d on clutch detentspring 15 mate with inner surface 12a of adjusting knob 12 and travel indetents 12b on inner surface 12a until a predetermined torque isencountered by units counter ring 36 which then causes clutch detentspring 15 to rotate with respect to adjusting knob 12. The importantfeature of the present invention is that when the clutch detent spring15 is manufactured with angle Θ of each outer leg 15c with respect torotational axis 15r, the clutch detent spring 15 is preset to providerelease from adjusting knob 12 at a predetermined torque.

As shown in FIG. 5a, cartridge retainer 18 is adapted for receiving acartridge 46 of the type including an internal piston 46b and apierceable seal 46a at one end thereof. A threaded end cap 19 isinserted through cartridge retainer 18 to extend from a distal end 18dof cartridge retainer 18 and is provided with threads 19a for securing adouble ended needle assembly 50. The proximal end of cartridge retainer18 includes the pair of bayonet lugs 18a on angular projections 18c thatengage with the pair of slots 16a at the distal end of center body 16.

Needle assembly 50 includes a cannula 50a having a sharp distal end 50bfor piercing the skin of a patient or user and a sharp proximal end 50cfor piercing pierceable seal 46a of cartridge 46 with a lumen (notshown) therethrough. Needle assembly 50 includes a cup-shaped hub 50dholding cannula 50a so that sharp proximal end 50c projects outwardlyfrom the interior of cup-shaped hub 50d. Cup-shaped hub 50d includes aninternal thread that is compatible with thread 19a on end cap 19, sothat needle assembly 50 may be removably attached to end cap 19 with itssharp proximal end 50c piercing pierceable seal 46a to establish fluidcommunication with the interior of cartridge 46.

The operation of the injection device 10 shall now be described withreference to the accompanying figures. Generally speaking, cartridge 46is loaded within the device, and a double ended needle assembly 50 isaffixed to the end of cartridge retainer 18. Fluid communication isaccordingly established between the injection portion of double endedneedle assembly 50 and the interior of cartridge 46. Once theappropriate dosage is set, push button 24 is urged forwardly, causinglead screw 26 to exert force upon piston 46b movably positioned withincartridge 46. Piston 46b displaces fluid within cartridge 46, causingits injection into body tissue through double ended needle assembly 50.The specific functions which are performed using the injection deviceare described separately herein. Assuming the device is loaded and pushbutton 24 is in the down position, three steps are followed in theinjection procedure: set to zero, set the dose, and make the injection.

First, adjusting knob 12 is rotated back to the zero setting on bothcounter rings 36 and 38. As will be described in more detailhereinbelow, adjusting knob 12 turns clutch detent spring 15 which thenturns units counter ring 36. Because the splines on units counter ring36 and plunger 22 are disengaged plunger 22 and the lead screw 26 do notturn. When rings 36 and 38 reach zero, their slots align and releaseupper spring member 42e of zero detection clip 42. This in turn releasesplunger 22 and push button 24 which move under pressure from spring 32via the two half nuts 28 until the proximal ends of large splines 22b ofplunger 22 are stopped by an inner surface of units counter ring 36.This movement also carries lead screw 26. Small splines 22d on theplunger 22 engage with the splined units counter ring 36 and are readyfor setting a dose.

Adjusting knob 12 is then rotated away from the zero (0) setting.Adjusting knob 12 turns clutch detent spring 15, which turns unitscounter ring 36, which turns plunger 22. Plunger 22 is engaged withlongitudinal grooves 26d in lead screw 26 which turns and screws forwardin the nut formed by the two half nuts 28. The lead screw's travel isproportional to the number of units displayed by the counter rings 36,38.

When the desired dose has been set, push button 24 is pushed fully inwhich pushes plunger 22, two half nuts 28, and lead screw 26 forwards.Plunger and lead screw 26, as coupled by half nuts 28, accordinglyperform the function of a piston rod. The total travel is determined bypush button 24 that slides into and is stopped by adjusting knob 12. Thefirst part of the travel brings the end of lead screw 26 into contactwith piston 46b of cartridge 46; the second part of the travel movespiston 46b of cartridge 46 forward and delivers the measured amount ofmedication. While setting the dose, lead screw 26 is moved forward inproportion to the dosage set; this distance determines the proportion ofthe pre-injection and injection travel. Plunger 22 and push button 24are locked in position by upper spring member 42e of the zero detectionclip 42 following an injection.

When a dose is set, units counter ring 36 pushes upper spring member 42eof zero detection clip 42 into its active position. Zero detection clip42 includes a clicker 42g that generates a click for each unit as itpasses over larger splines 22b on plunger 22. Units counter ring 36drives the tens counter ring 38 through 36 degrees of rotation everytime units counter ring 36 passes zero via transmission key 44. Lowerspring member 42e of zero detection clip 42 has a ridge 42d whichengages with the grooves 38a inside the tens counter ring 38 and createsa click every time the tens counter ring 38 turns.

If the dose is set at the maximum dialable dose (hereinafter "TMDD"),tens counter ring 38 reaches a stop, and transmission key 44 engages inthe last location in the tens counter ring 38. If adjusting knob 12 isturned further, rings 36 and 38 are unable to turn and adjusting knob 12slips without further effect. Clutch detent spring 15 is designed tolimit the torque which will be transmitted to the counter rings andprevents unintentional damage.

The travel of lead screw 26 is limited to the safe travel of piston 46bin the cartridge 46. If lead screw 26 reaches the end of its travel,projections 22c inside plunger 22 reach the end of grooves 26d in leadscrew 26 and prevent it from further movement. Lead screw 26 preventsplunger 22 and counter rings 36 and 38 from turning. Adjusting knob 12will then cause clutch detent spring 15 to slip without further effect.The counter rings will indicate the travel of the lead screw to thispoint, and therefore, the quantity of insulin remaining in thecartridge.

When adjusting knob 12 is rotated away from the zero (0) setting, andthere are more than TMDD units remaining in cartridge 46, the counterrings will stop at TMDD units as described above. If there are less thanTMDD units remaining, the counter rings will stop as described above anddisplay the remaining capacity of cartridge 46. In either case, the usercan then turn adjusting knob 12 back until the counter rings display thedose to be administered.

After a complete injection has been made, push button 24 can be left inthe loading position. As described above, when device 10 is in theloading position cartridge retainer 18 can be removed from center body16 of housing 20 and cartridge 46 can be removed. When cartridgeretainer 18 is removed from housing 20, the elliptical shape defined bythe inner wall of locking ring 30 allows two half nuts 28 to open underpressure from spring 32 and to free lead screw 26, as shown in FIG. 11.

A new cartridge 46 can then be inserted into cartridge retainer 18 whichis then locked back onto center body 16 using the bayonet or lugs 18a oncartridge retainer 18. As cartridge retainer 18 moves towards centerbody 16, piston 46b of cartridge 46 will push lead screw 26 into thedevice. Cartridge retainer 18 has two angular projections 18c thatengage with angular projections 30c extending from locking ring 30. Whencartridge retainer 18 is then rotated the projections 18c and 30c causelocking ring 30 to turn the same amount. In addition, after cartridgeretainer 18 has rotated and each lug 18a on cartridge retainer 18 hasentered its respective recess 16b in slot 16a inside center body 16,cartridge retainer 18 is prevented from turning further. The ellipticalinner wall of locking ring 30 moves two half nuts 28 into engagementwith lead screw 26. The position of lead screw 26 is then determined bythe position of the piston 46b in cartridge 46.

Upper body 14 houses the four parts which comprise the countermechanism. Window 34 in upper body 14 shows the numbers printed on theoutside of the two counter rings 36 and 38, and indicates the number ofunits to be injected from 0 to TMDD. Units counter ring 36 is turned byadjusting knob 12 through clutch detent spring 15. When units counterring 36 has turned to numbered position "8", transmission key 44 meetsthe cam molded inside upper body 14. The transmission key 44 is thenforced to slide up the face of the cam, and reaches the top in position"9". The elastic ring 40 is flexed by this movement and maintains thetransmission key 44 in contact with the cam. This movement also bringsthe opposite end of transmission key 44 into engagement with one of theslots 38b inside the tens counter ring 38, shown in FIG. 5b. When unitscounter ring 36 is turned further, transmission key 44 transmits themovement to tens counter ring 38, and the two rings turn together. Atposition "10" the window 34 now displays "10" and transmission key 44has rotated 36 degrees to the end of the raised face of the cam insidethe upper body 14.

If units counter ring 36 is turned further, transmission key 44 is freeto slide down the face of the cam inside upper body 14 under pressurefrom elastic ring 40. This movement disengages the two counter rings,and the counter will now read "11". This movement is repeated each timethe units counter ring 36 moves from position "8", through positions "9"and "0" to position "1". The reverse procedure is identical.

The tens counter ring 38 has stops in the "0" and TMDD positions toprevent the counter mechanism from going beyond a maximum reading ofTMDD or a minimum reading of 0 units. In both of these positions thetransmission key 44 is in its active, engaged position. It should benoted that if the stops for the tens counter ring 38 were moved, thereading could continue up to 99 units.

The slot in units counter ring 36 has an angled face which works as acam, forcing the upper spring member 42e down into its active positionas soon as the units counter ring 36 leaves the "0" position. The unitscounter ring 36 holds the zero detection clip 42 in its active positionup to position "9". In position "10" the tens counter ring 38 has moved,and now holds the zero detection clip 42 in its active position. Fromposition "10" to position TMDD zero detection clip 42 is held in itsactive position by tens counter ring 38. When an injection is made,plunger 22 slides through the zero detection clip 42 until the end ofits travel. At this point the end of upper spring member 42e dropsbehind the end of spline 22b and prevents plunger 22 from moving outunder pressure from spring 32. The components can be designed so thatthis movement will make a clicking sound, confirming that a completeinjection has been made.

When the counter is set to "0" as shown in FIG. 10, the slots inside thetwo counter rings 36 and 38 align with upper spring member 42e of zerodetection clip 42 and allow it to spring up into its rest position. Thismovement frees plunger 22 and allows a new dose to be set.

Cartridge 46 is easily loaded and substantially fully visible to theuser. Two way dosage adjustment is possible, which allows corrections tobe made quickly and easily. The dosage to be administered is clearlydisplayed and will remain displayed subsequent to the injectionprocedure. In order to insure that a complete injection has been made,the device produces a click and locks in the closed position only whenthe plunger is fully inserted.

While the invention has been described with respect to a preferredembodiment illustrated in FIGS. 1-14, it should be understood thatvariations from this preferred embodiment may be provided, and areconsidered to be within the scope of the subject invention.

What is claimed is:
 1. A medication delivery pen comprising:a housinghaving a distal end and a proximal end; a cartridge retainer forreceiving a cartridge containing medication, said cartridge retainerbeing removably mountable on the distal end of said housing; means insaid housing for setting a desired dose of medication to be dispensedfrom the cartridge having a rotatable dose setting knob and a dosingring that displays the amount of the desired dose being set; means insaid housing for dispensing the desired dose of medication from thecartridge; and means in said dose setting means for controlling torqueapplied by said rotatable dose setting knob to said dosing ring duringrotation of said dosing knob including a clutch having a clutch detentspring attached to said dosing ring and rotatable mounted to said dosesetting knob to rotate within said dose setting knob when apredetermined torque is applied to said dose setting knob.
 2. Amedication delivery pen according to claim 1, wherein said clutch detentspring includes a plurality of outer legs and a plurality of internaltabs, wherein said internal tabs attach to said dosing ring and saidouter legs are in sliding contact with said dose setting knob.
 3. Amedication delivery pen according to claim 2, wherein said dose settingknob includes a plurality of detents on an inner surface and each ofsaid plurality of outer legs on said clutch detent spring includesprotrusion that rides in a respective one of said plurality of detentsuntil said predetermined torque is applied to said dose setting knob,which then causes each of said plurality of protrusions to slip out ofeach of said plurality of detents.
 4. A medication delivery penaccording to claim 3, wherein each of said outer legs are positioned ata predetermined angle Θ such that said predetermined torque can beapplied to said dosing ring by said dose setting knob.
 5. A medicationdelivery pen according to claim 1, further comprising attachment meansbetween said cartridge retainer and said housing for attaching andunattaching said cartridge retainer to said housing.
 6. A medicationdelivery pen according to claim 5, wherein said attachment means is abayonet.
 7. A medication delivery pen according to claim 6, wherein saidbayonet includes a pair of projections on the proximal end of saidcartridge retainer and a pair of slots in the distal end of saidhousing.